Non-Catalytic Roles of Presenilin Throughout Evolution
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چکیده
منابع مشابه
Non-Catalytic Roles of Presenilin Throughout Evolution
Research into Alzheimer's disease pathology and treatment has often focused on presenilin proteins. These proteins provide the key catalytic activity of the γ-secretase complex in the cleavage of amyloid-β precursor protein and resultant amyloid tangle deposition. Over the last 25 years, screening novel drugs to control this aberrant proteolytic activity has yet to identify effective treatments...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2016
ISSN: 1387-2877,1875-8908
DOI: 10.3233/jad-150940